DriverDBv5: A database for human cancer driver gene research
What is DriverDBv5?
A comprehensive cancer omics database for identifying and characterizing driver genes across multiple cancer types. It integrates diverse molecular data — including somatic mutations, RNA, miRNA, protein, methylation, and CNV — alongside clinical information and curated annotations, now spanning 187 cancer cohorts, 43,862 patients, and 129,655 samples. Through three intuitive interfaces — Cancer, Gene, and Customized Analysis — researchers can explore complex relationships between specific cancers and their associated driver genes, enabling deeper insights into cancer biology and mechanisms.
Search by Functions
The ‘Cancer’ function explores driver genes and miRNA drivers associated with the selected cancer type and their functional roles across multiple omics layers. (View example: Lung adenocarcinoma)
The ‘Gene’ function explores a selected gene across cancers, integrating expression, mutation, CNV, methylation, protein, miRNA regulation, survival, and multi-omics evidence to characterize its potential driver roles. (View example: EGFR)
The ‘Customized Analysis’ function provides five analyses: subgroup analysis, survival analysis, multi-omics driver analysis, signature identification and Multivariate survival analysis.
(View examples:
Subgroup,
Survival,
Multi-omics Driver,
Signature Identification, and Multivariate Survival)
Schematic representation of DriverDBv5
News & Updates
- 2026.06.22 Launch DriverDBv5
- 2025.08.29 Enhanced high-resolution download feature, available for publication
- 2025.07.29 Launch three new modules in Customized-analysis
- 2023.11.13 Publish DriverDBv4 in Nucleic Acids Res.
- 2023.08.04 Launch DriverDBv4
- 2019.11.08 Publish DriverDBv3 in Nucleic Acids Res.
- 2019.07.22 Launch DriverDBv3
- 2015.12.03 Publish DriverDBv2 in Nucleic Acids Res.
- 2015.08.18 Launch DriverDBv2
- 2013.11.07 Publish DriverDBv1 in Nucleic Acids Res.
- 2013.07.13 Launch DriverDBv1
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