DriverDBv4: A database for human cancer driver gene research

What is DriverDBv4?

DriverDBv4 is a cancer omics database which incorporates somatic mutation, RNA expression, miRNA expression, protein expression, methylation, copy number variation and clinical data in addition to annotation bases. This database also uses published bioinformatics algorithms to identify driver genes and present them with different molecular features; there are three functions, ‘Cancer‘, ‘Gene’, and ‘Customized-Analysis’, to help researchers visualize the relationships between cancers and driver genes.

Search by Functions

The ‘Cancer’ function summarizes the calculated results of driver genes in different molecular features by using published bioinformatics algorithms or tools for a specific cancer type or dataset.

Example : EGFR

The ‘Gene’ function visualizes different features of a user-selected gene within cancer types or datasets.

The ‘Customized-Analysis’ function provides three analyses: survival analysis, multi-omics driver analysis, and subgroup expression analysis. In survival analysis, researchers can stratify patients using two approaches: by expression levels or by mutation status. The multi-omics driver analysis identifies and explores the multi-omics drivers associated with user-defined groups of patients. The subgroup expression analysis visualizes gene expression patterns concerning specific clinical factors.


Chia-Hsin Liu, Yo-Liang Lai, Pei-Chun Shen, Hsiu-Cheng Liu, Meng-Hsin Tsai, Yu-De Wang, Wen-Jen Lin, Fang-Hsin Chen, Chia-Yang Li, Shu-Chi Wang, Mien-Chie Hung, Wei-Chung Cheng, DriverDBv4: a multi-omics integration database for cancer driver gene research, Nucleic Acids Research, 2023;, gkad1060,

Schematic representation of DriverDBv4

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